![]() This barrier has to withstand the mechanical stresses to which epithelial cells are exposed, for instance, during morphogenetic movements ( Takeichi, 2014 Lecuit and Yap, 2015). Our data thus identify an asymmetric mechanoresponse at cadherin adhesions during mitosis, which is essential to maintain epithelial integrity while at the same time enable the shape changes of mitotic cells.Įpithelia cover the body surface and organs to form a regulated barrier between the internal and external environment. ![]() Conversely, the absence of vinculin from the cadherin complex in mitotic cells is necessary to successfully undergo mitotic rounding. Inhibition of junctional vinculin recruitment in neighbors of mitotic cells results in junctional breakage and weakened epithelial barrier. Surprisingly, vinculin that is recruited to mitotic junctions originates selectively from the neighbors of mitotic cells, resulting in an asymmetric composition of cadherin junctions. We find that mitotic cell–cell junctions withstand these tensile forces through the mechanosensitive recruitment of the actin-binding protein vinculin to cadherin-based adhesions. ![]() Here, we show that as epithelial cells round up when they enter mitosis, they exert tensile forces on neighboring cells. Epithelia are continuously self-renewed, but how epithelial integrity is maintained during the morphological changes that cells undergo in mitosis is not well understood.
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